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Aurora A Kinases
From 1 mM to 19 nM (50,000 fold increase) Aurora kinases are a family of serine/threonine kinases that are essential for cell division via regulating mitosis. Researchers have proposed them as a novel therapy target for many cancers, with in vivo and in vitro studies supporting this. There are 3 types of Aurora Kinase, A, B and C. Aurora A kinase is activated through its interaction with Targeting protein for Xenopus kinesin-like protein 2 (TPX2) and represents a promising target for cancer...